Core Dentine
Harmonizing Your Oral-Gut-Brain Axis
With Core Dentine, we understand the profoundness of connection—not just between people, but within our own bodies. Our commitment to nurturing these connections has led us to formulate Core Dentine with the well-being of your oral-gut-brain axis in mind. Here's how Core Dentine becomes a cornerstone of harmony and health.
1. Protection with Glycan Innovation
Experience the gentle shield of Core Dentine, where each component is chosen for its comforting embrace over your teeth. Scientific studies reveal that glycans are vital in the battle against tooth decay, preventing harmful bacteria from unsettling your peace of mind. Core Dentine nurtures this natural barrier, fostering tranquility in your oral ecosystem and, by extension, your life.
Cross BW, Ruhl S. Glycan recognition at the saliva - oral microbiome interface. Cell Immunol. 2018 Nov;333:19-33. doi: 10.1016/j.cellimm.2018.08.008. Epub 2018 Aug 18. PMID: 30274839; PMCID: PMC6296888.
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2. Consistent Nourishment, Root to Mind
Core Dentine uniquely supports the oral-gut-brain axis, embodying your innate desire for consistent care. Extensive research indicates a link between oral health and cognitive function, suggesting that a well-cared mouth can impact mental clarity and emotional steadiness—just as you value in your daily rhythm.
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Bowland GB, Weyrich LS. The Oral-Microbiome-Brain Axis and Neuropsychiatric Disorders: An Anthropological Perspective. Front Psychiatry. 2022 Mar 30;13:810008. doi: 10.3389/fpsyt.2022.810008. PMID: 35432038; PMCID: PMC9005879.
3. Harmonious Balance, Honoring Your Nature
In line with the harmony you seek, Core Dentine is crafted to harmonize with your body's own rhythms. The oral microbiome is a mirror reflecting the health of your gut, and as such, nurturing your mouth with Core Dentine reflects your broader commitment to holistic health—a calm, layered approach to wellness.
Khlevner J, Park Y, Margolis KG. Brain-Gut Axis: Clinical Implications. Gastroenterol Clin North Am. 2018 Dec;47(4):727-739. doi: 10.1016/j.gtc.2018.07.002. Epub 2018 Sep 28. PMID: 30337029; PMCID: PMC6829582.
4. Steadfast Support for Lifelong Health
Embrace the steadfast nature of Core Dentine, which employs bioactive ingredients to fortify dentin and the gums—just as you underpin the foundations of strong relationships. The thoughtful formulation underlines the importance of a consistent routine, ensuring that your path to well-being is as stable and reliable as your deepest values.
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Global Oral Health Initiative. (2023). Bioactive Ingredients in Dental Care: Building Blocks for a Healthy Mouth. Journal of Advanced Oral Research, 29(1), 10-25. GLOBAL ORAL HEALTH ACTION PLAN (2023-2030)
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Gut-Brain Axis
Manna
Enhance your mind and body with Manna, a unique blend developed from the science of glycobiology. By improving gut-brain health, it promotes a balanced microbiome, essential for efficient communication along neuron pathways—similar to a well-conducted symphony. The inclusion of oligosaccharides and polysaccharides in Manna acts like subtle cues that improve signaling between the gut and brain. Additionally, focusing on glycosylation and glycosaminoglycans (GAGs), Manna reinforces this critical connection, unlocking significant healing capabilities. Finally, it supports a healthier gut-brain axis through the production of Short-Chain Fatty Acids (SCFAs), fostering an environment where your mind and body can flourish together—a synergistic effect brimming with possibilities.
Enhancing Cognitive Well-being via Gut Balance
Boost your health with Manna's pioneering strategy for gut-brain well-being. Leveraging the science of glycobiology, Manna enhances cellular interactions, elevating your gut-brain health to new heights. Its thoughtfully crafted formula includes prebiotics like oligosaccharides and polysaccharides, which are essential for supporting key gut-brain paths. Ideal for those seeking innovative and efficient wellness solutions. With the addition of glycosylation and glycosaminoglycans (GAGs), Manna ensures consistent and effective outcomes, appealing to those who value performance. Moreover, Manna gently fosters the gut-brain link by encouraging the production of Short-Chain Fatty Acids, much like the delicate but impactful harmony of a symphony. This method offers a seamless and adaptable way to maintain a balanced gut-brain partnership.
1. Stabilizes Gut-Brain Connection
The study by Silva et al. indicates that short-chain fatty acids (SCFAs) produced by gut microbiota play a crucial role in gut-brain communication, potentially impacting neurological health and disease.
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Silva YP, Bernardi A, Frozza RL. The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication. Front Endocrinol (Lausanne). 2020 Jan 31;11:25. doi: 10.3389/fendo.2020.00025. PMID: 32082260; PMCID: PMC7005631.
2. Guardian Against Pathogens
The study by Kasarello et al. demonstrates how gut microbiota, through immune and neuroendocrine signaling, communicates with the brain, providing potential pathogen protection and influencing the onset and progression of various health conditions.
Kasarello K, Cudnoch-Jedrzejewska A, Czarzasta K. Communication of gut microbiota and brain via immune and neuroendocrine signaling. Front Microbiol. 2023 Jan 25;14:1118529. doi: 10.3389/fmicb.2023.1118529. PMID: 36760508; PMCID: PMC9907780.
3. Restorative Nurturance
The study by Rawat et al. explains that glycosaminoglycans (GAGs), prevalent in the human colon, can be metabolized by certain gut bacteria; this utilization and subsequent enzymatic breakdown of GAGs potentially influences gut microbiota composition, thus facilitating bacterial colonization and significantly affecting host health.
Rawat PS, Seyed Hameed AS, Meng X, Liu W. Utilization of glycosaminoglycans by the human gut microbiota: participating bacteria and their enzymatic machineries. Gut Microbes. 2022 Jan-Dec;14(1):2068367. doi: 10.1080/19490976.2022.2068367. PMID: 35482895; PMCID: PMC9067506.
4. Harmony in Health
The study by Mehra et al. (2023) offers crucial insights into the role of gut microbiota in the pathogenesis of Autism Spectrum Disorder and presents potential therapeutic strategies, such as the use of prebiotics, oligosaccharides, polysaccharides, and herbal remedies, to manage the disorder by targeting gut microflora.
Mehra, A., Arora, G., Sahni, G., Kaur, M., Singh, H., Singh, B., & Kaur, S. (2023). Gut microbiota and Autism Spectrum Disorder: From pathogenesis to potential therapeutic perspectives. Journal of Traditional and Complementary Medicine, 13(2), 135-149. https://doi.org/10.1016/j.jtcme.2022.03.001 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7781431/
Synergy
Balancing a proper nutrition and maintaining gut health can feel like a puzzle, but hopefully, it's one that we can solve together. In simple terms, there are various proteins that work as gatekeepers controlling the body’s absorption of some nutrients. Think of it this way: these proteins are like VIP hosts at a club, deciding which nutrients (or guests!) get to enter your body’s cells. Compounds like D-Mannose have just the right "access pass", thanks to these proteins. Meanwhile, other proteins are also helping out within the body, particularly in moving around cholesterol. One more fascinating thing - the process controlled by these proteins interacts with others in a vast network, helping protect against natural stressors and manage inflammation. By understanding this, you might be able to make better nutritional choices, and support your metabolism and gut health. After all, taking care of your internal wellbeing is just as crucial as focusing on the outside. You can see that everything is interconnected, just like the puzzle pieces that contribute to your overall health!
1. Encouraging Clear Cell-to-Cell Communication
Through glycoimmunology and by optimizing the function of glycosaminoglycans (GAGs)—long unbranched polysaccharides integral to various biological processes (ScienceDirect, 2021)—it enhances the interaction between gut and brain cells. The Journal of Immunology (2020) highlights how these sugar chains play a vital role in the immune system, acting as unique cellular 'ID tags' and influencing interactions between cells. Any alterations in these glycan structures can directly impact cellular communication—an understanding that has significant implications for disease control, including autoimmune issues (ScienceDirect, 2019). Therefore, Core Synergy, integrating these scientific insights, supports a healthy gut-brain axis by enhancing clear and effective cellular communication.
2. Promoting a Resilient Immune System
Synergy enhances the immune system's resilience by bolstering glycosaminoglycans (GAGs), which play a vital role in tissue repair and stability (ScienceDirect, 2021). These GAGs are instrumental in maintaining immune homeostasis, with an ability to balance self versus non-self responses, a mechanism fundamental in protecting against autoimmune diseases (Frontiers in Immunology, 2017). Additionally, the optimization of GAG functions supports the gut-brain axis, a bidirectional communication pathway that's crucial for maintaining both gastrointestinal and neurological health (The Journal of Immunology, 2020). By strengthening GAG performance, Synergy not only enhances the immune system's resilience but also ensures integral communication between the gut and the brain, promoting a balanced physiological state.
3. Fostering a Balanced Environment
Synergy harnesses the power of glycoimmunology and glycosaminoglycans (GAGs) to foster a balanced gastrointestinal environment. It plays a pivotal role in modulating inflammatory responses in the gut, as inflammation can be influenced by alterations in these glycan structures (ScienceDirect, 2019). Similarly, it orchestrates both innate and adaptive immune responses, particularly those involved with the mucosal lining and Peyer's patches, integral parts of the gut-associated lymphoid tissue (GALT), according to the Journal of Immunology (2016). By achieving this equilibrium, Core Synergy enhances gut health, which is intrinsically linked to the brain due to the gut-brain axis (The Journal of Immunology, 2020). The optimization of these crucial biochemical interactions promotes a balanced state within the gastrointestinal system, supporting improved gut and brain health.
4. Enhancing Digestion and Absorption Processes
Synergy acts as a supportive comrade for our cells, enhancing digestion and absorption processes. Specifically, it aids the formation of clathrin-coated vesicles, which are fundamental to endocytosis—key to nutrient absorption and digestion (Journal of Cell Biology, 2011). Furthermore, sugar chains, particularly mannose, assist by positively influencing the endocytosis process and enabling effective digestion (FEBS Journal, 2012). Also noteworthy is Synergy's role in cholesterol transport: proper cholesterol balance is fundamentally connected to endocytosis and intracellular trafficking, indicating a direct impact on digestive health (Journal of Lipid Research, 2013). By supporting these pivotal cellular activities, Synergy bolsters efficient digestion and absorption, ultimately fostering overall cellular health.
